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Several United Nations agencies condemned the use of starvation as a weapon of war, as malnutrition rates in Gaza spike under Israeli siege. During the UN Food Systems Summit Stocktake taking place in Addis Ababa, Secretary-General António Guterres stressed: "Hunger fuels instability and undermines peace. We must never accept hunger as a weapon of war." Guterres' statement follows Israel's decision to permit a one-week scale-up of humanitarian aid into the Gaza Strip, where famine conditions now prevail. UN agencies welcomed the easing of aid restrictions and so-called "humanitarian pauses" in the ongoing bombardment; however, as emphasized by UN Emergency Relief Coordinator Tom Fletcher: "This is progress, but vast amounts of aid are needed to stave off famine and a catastrophic health crisis."

At a meeting of European Union foreign ministers in Brussels, the bloc opted not to take punitive action against Israel over widespread evidence of war crimes and atrocities committed in Gaza. For weeks, the EU had been discussing a range of potential actions, including: suspending its free trade agreement with Israel, an arms embargo, banning the import of products from Israeli settlements in the occupied West Bank, and ending visa-free travel for Israeli citizens. Instead of taking any of these measures—which advocates argue are necessary to avoid complicity in serious violations of international law—EU ministers pointed to an aid deal for Gaza struck days earlier as justification for inaction. The details of that deal remain vague, and it has so far shown little on-the-ground impact. Amnesty International assailed the apparent quid pro quo as a "cruel and unlawful betrayal" of the Gazans.

The Office of the United Nations High Commissioner for Human Rights (OHCHR) announced that the recent killing of Palestinians trying to receive food from aid hubs may constitute a war crime, warning of a policy of "weaponized hunger" in the Gaza Strip. Jonathan Whittall, the head of the United Nations Office for the Coordination of Humanitarian Affairs (OCHA) in Gaza and the West Bank, reported that more than 400 people have now died in the process of trying to reach food distribution points. "We see a chilling pattern of Israeli forces opening fire on crowds gathering to get food," Whittall said, adding that "Israel's militarized humanitarian assistance mechanism is in contradiction with international standards on aid distribution."

Two days after the US carried out air-strikes against Iran's nuclear sites in what is being dubbed Operation Midnight Hammer, Iran launched missiles at al-Udeid air base in Qatar, headquarters for US Central Command's regional operations and host to some 8,000 US troops. The US said nearly all the missiles were intercepted and there were no casualties. In a post on TruthSocial, President Trump shortly later claimed a ceasefire between Israel and Iran has been reached, with Israeli media reporting that the truce was brokered by Qatar. Sources also told Reuters that Iran had tipped off Qatar authorities before the attack, who then warned the US—accounting for the light damage and raising the possibility that, as in US-Iran brinkmanship of early 2020, the supposed Iranian retaliation was choreographed to allow Tehran to save face. The US, Israel and Iran alike are now all claiming victory, and it remains unclear how seriously Tehran's nuclear capabilities have in fact been degraded.

UN Secretary-General António Guterres urged both Iran and Israel to exercise "maximum restraint" amid a sudden escalation between the two states following Israeli attacks on Iran's nuclear installations. Condemning the Israeli strikes, the statement from the secretary-general's office expressed concerns about a wider conflagration throughout the Middle East, warning that "a descent into deeper conflict" would be "a situation that the region can hardly afford."

Commissioner-General of the United Nations Relief & Works Agency for Palestine Refugees (UNRWA) Philippe Lazzarini urged Israel to lift the aid blockade in Gaza, charging that under Israeli military control "aid distribution has become a death trap."  Lazzarini asserted that aid distribution can only be effectively achieved through the United Nations. He demanded that Israel allow the UN to manage a safe and at-scale delivery of aid in Gaza, calling this "the only way to avert mass starvation including among 1 million children."

The US Department of State imposed sanctions on on four individuals serving as judges on the International Criminal Court (ICC) for their involvement with the ICC’s investigations into the US and Israel. The sanctions were imposed pursuant to Executive Order No. 14,203, "Imposing Sanctions on the International Criminal Court," which President Donald Trump signed in February in response to the ICC's warrants for Israeli Prime Minister Benjamin Netanyahu and former defense minister Yoav Gallant. The stated purpose of the order was to underline the position that the US and Israel are not within the jurisdiction of the ICC under the Rome Statute, and therefore any investigation into the actions of the two countries is invalid.